Inhibition of platelet function by organic nitrate vasodilators
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چکیده
منابع مشابه
Inhibition of platelet function by organic nitrate vasodilators.
There is evidence that platelet activation in the coronary circulation may be important in the pathogenesis of myocardial ischemia. Since organic nitrate vasodilators are commonly used in coronary artery disease, we have studied the in vitro effects of these drugs on platelet function. Nitroglycerin, isosorbide dinitrate, and their biotransformation product, inorganic nitrite, inhibited platele...
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Organic nitrates have been used to relieve angina since Brunton (l) first described their use in 1867. The assumption has been that nitrates decrease myocardial oxygen demand by reducing preload and afterload. In the last 20 years it has been established that unstable angina and possibly silent ischemia at rest are often due to platelet aggregates forming in stenosed coronary arteries. This pla...
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ژورنال
عنوان ژورنال: Blood
سال: 1980
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v55.4.649.bloodjournal554649